Transgenic models do not exist for which of the following diseases?

In $1997$,the first transgenic cow,Rosie,produced:

Transgenic animals are animals in which a foreign gene is expressed. Such animals can be used to study fundamental biological processes and phenomena, as well as for producing products useful for mankind. Give one example for each type.

The first transgenic cow was developed in the year:

The human protein $\alpha-1$ antitrypsin is obtained from

Match the following:

Column-$I$	Column-$II$
$(1)$ Study of disease	$(p)$ Transgenic mice
$(2)$ Biological products	$(q)$ Testing toxicity of drug
$(3)$ Vaccine safety	$(r)$ Rheumatoid arthritis
$(4)$ Chemical safety	$(s)$ $\alpha-1$ Antitrypsin