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(B) Transgenic animals are defined as animals that have had their $DNA$ manipulated to possess and express an extra (foreign) gene.In the process of c

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all of their cells contain foreign $DNA$.

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(B) Transgenic animals are defined as animals that have had their $DNA$ manipulated to possess and express an extra (foreign) gene.In the process of creating a transgenic animal,the foreign gene is introduced into the germline cells (such as the zygote or early embryonic cells).As a result,the foreign $DNA$ becomes integrated into the genome of the organism.Since this integration occurs at the embryonic stage,the foreign $DNA$ is replicated and passed on to every cell of the developing organism.Therefore,all cells of a transgenic animal contain the foreign $DNA$.

Column-$I$	Column-$II$
$(1)$ Study of disease	$(p)$ Transgenic mice
$(2)$ Biological products	$(q)$ Testing toxicity of drug
$(3)$ Vaccine safety	$(r)$ Rheumatoid arthritis
$(4)$ Chemical safety	$(s)$ $\alpha-1$ Antitrypsin

Transgenic animals are those in which ........ .

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