Analogy type questions:
$(1)$ Middle lamella : Calcium pectate :: Cytochrome : ........
$(2)$ Thiamine : Vitamin :: Manganese : ........

(A) $(1)$ Iron $(Fe)$: Cytochrome is a protein that contains iron as a central metal ion,which is essential for electron transport in respiration and photosynthesis.
$(2)$ Photolysis of water: Manganese $(Mn^{2+})$ is a critical micronutrient required for the photolysis of water during the light-dependent reactions of photosynthesis.