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(A) The sequence of amino acids in a protein is determined by the sequence of nucleotides in the $DNA$ molecule.During the process of protein synthesi

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$DNA$

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(A) The sequence of amino acids in a protein is determined by the sequence of nucleotides in the $DNA$ molecule.During the process of protein synthesis,$DNA$ is transcribed into $mRNA$,which is then translated into a polypeptide chain by ribosomes.Any mutation or change in the nucleotide sequence of the $DNA$ (such as point mutations,insertions,or deletions) directly alters the codon sequence in the $mRNA$.This change in the $mRNA$ sequence results in the incorporation of a different amino acid or a change in the total number of amino acids in the resulting protein chain.

$A$ change in which of the following leads to an alteration in the sequence or number of amino acids in a protein?

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