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(A) The first clinical gene therapy was performed in $1990$ on a $4$-year-old girl suffering from Adenosine Deaminase $(ADA)$ deficiency.$ADA$ enzyme

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Adenosine Deaminase $(ADA)$ deficiency

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(A) The first clinical gene therapy was performed in $1990$ on a $4$-year-old girl suffering from Adenosine Deaminase $(ADA)$ deficiency.$ADA$ enzyme is crucial for the proper functioning of the immune system.In this therapy,lymphocytes from the patient's blood were grown in a culture outside the body.$A$ functional $ADA$ $cDNA$ was then introduced into these lymphocytes using a retroviral vector.These genetically engineered lymphocytes were subsequently returned to the patient's body.Since these cells are not immortal,the patient requires periodic infusion of such genetically engineered lymphocytes.

List-$I$	List-$II$
$A$. Genetically engineered Human Insulin	$I$. Gene therapy
$B$. $\text{GM}$ Cotton	$II$. $\text{E. coli}$
$C$. $\text{ADA}$ Deficiency	$III$. Antigen-antibody interaction
$D$. $\text{ELISA}$	$IV$. $\text{Bacillus thuringiensis}$

The first clinical gene therapy was given in $1990$ to a $4$-year-old girl for the treatment of which disease?

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