A : 2,4-DNP (2,4-Dinitrophenol) is an uncoupl | vedclass

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Question

(A) $2,4-DNP$ $(2,4-Dinitrophenol)$ acts as an uncoupling agent because it is a lipid-soluble proton ionophore. It facilitates the movement of protons

Vedclass · Accepted Answer

Assertion and Reason both are correct and Reason is the correct explanation of Assertion.

Vedclass · Answer

(A) $2,4-DNP$ $(2,4-Dinitrophenol)$ acts as an uncoupling agent because it is a lipid-soluble proton ionophore. It facilitates the movement of protons $(H^+)$ across the inner mitochondrial membrane,bypassing the $ATP$ synthase enzyme. As a result,the proton gradient is dissipated,which prevents the synthesis of $ATP$ while allowing electron transport to continue. Thus,both the Assertion and Reason are correct,and the lipid solubility of $DNP$ is the reason it can act as an uncoupler.

$A$ : $2,4-DNP$ $(2,4-Dinitrophenol)$ is an uncoupling agent of $ETS$.
$R$ : It is soluble in lipids.

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$A$ : $2,4-DNP$ $(2,4-Dinitrophenol)$ is an uncoupling agent of $ETS$.$R$ : It is soluble in lipids.