(D) mutation that involves a change in a single base pair of $DNA$ is called a $Point$ mutation. For example,the classic case of $Sickle-cell$ $anemia

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(D) mutation that involves a change in a single base pair of $DNA$ is called a $Point$ mutation. For example,the classic case of $Sickle-cell$ $anemia$ is caused by a single base pair substitution in the gene for $\beta-globin$ chain,where $GAG$ is replaced by $GUG$.