The base sequence of a segment of DNA is AAG, | vedclass

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(B) frame-shift mutation occurs due to the insertion or deletion of one or more nucleotides in a $DNA$ sequence,which alters the reading frame of the

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$AAG, AGG, ACC, AAC, CAA$

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(B) frame-shift mutation occurs due to the insertion or deletion of one or more nucleotides in a $DNA$ sequence,which alters the reading frame of the genetic code.Original sequence: $AAG, GAG, GAC, CAA, CCA$ ($15$ bases).In option $B$: $AAG, AGG, ACC, AAC, CAA$,the reading frame has shifted significantly compared to the original sequence,indicating an insertion or deletion event occurred. Options $C$ and $D$ represent point mutations (substitutions),where only a single base is changed without altering the entire reading frame downstream. Therefore,option $B$ is the correct representation of a frame-shift mutation.

Column $I$	Column $II$
$1$. Ligase	$a$. Peptide bond formation
$2$. Ribozyme	$b$. Hydrolysis of lactose
$3$. Permease	$c$. Joining of Okazaki fragments
$4$. $\beta$-galactosidase	$d$. Increases permeability

The base sequence of a segment of $DNA$ is $AAG, GAG, GAC, CAA, CCA$. Which of the following sequences represents a frame-shift mutation?

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