Which of the following is a gene mutation?

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(D) gene mutation is a permanent alteration in the $DNA$ sequence that makes up a gene. Such mutations involve changes in the sequence of nitrogenous

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Change in the sequence of nitrogenous bases

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(D) gene mutation is a permanent alteration in the $DNA$ sequence that makes up a gene. Such mutations involve changes in the sequence of nitrogenous bases (nucleotides) within the $DNA$ molecule. While chromosomal mutations involve large-scale changes to the structure or number of chromosomes,gene mutations (also known as point mutations) specifically refer to alterations in the base sequence of a single gene. Therefore,a change in the sequence of nitrogenous bases is the most accurate description of a gene mutation.

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