According to the lock and key hypothesis,which complex is formed when an enzyme binds to a substrate?

Identify $P, Q,$ and $R$ in the following descriptions:
$P -$ The component that undergoes transformation in a chemical reaction.
$Q -$ The component formed as a result of transformation in a chemical reaction.
$R -$ The component that remains unchanged after the completion of a chemical reaction.
What are $P, Q,$ and $R$ respectively?

Which one of the following enzymes is composed of simple proteins?

Assertion : Enzymes have active sites and substrates have reactive sites on their surface respectively.
Reason : Active and reactive sites push the enzyme and substrate molecules away from each other.

$A$: In a feverish condition,the rate of physiological processes in the body decreases.
$R$: Enzymes are temperature-sensitive.

Which of the following enzymes is $NOT$ regulated by calcium?