Which of the following compounds is most reac | vedclass

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(A) The reactivity of carbonyl compounds towards nucleophilic attack depends on the electrophilicity of the carbonyl carbon and the leaving group abil

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$MeCOCl$

Vedclass · Answer

(A) The reactivity of carbonyl compounds towards nucleophilic attack depends on the electrophilicity of the carbonyl carbon and the leaving group ability. Acid chlorides $(RCOCl)$ are the most reactive because the $Cl^-$ ion is an excellent leaving group and the electron-withdrawing effect of the chlorine atom increases the electrophilicity of the carbonyl carbon. Therefore,$MeCOCl$ is the most reactive among the given options.

Which of the following compounds is most reactive towards nucleophilic attack on the carbonyl group?

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