(D) The energy produced in a nuclear reaction is given by Einstein's mass-energy equivalence principle,which is expressed by the equation $E = mc^2$,w

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(D) The energy produced in a nuclear reaction is given by Einstein's mass-energy equivalence principle,which is expressed by the equation $E = mc^2$,where $E$ is the energy,$m$ is the mass defect,and $c$ is the speed of light in a vacuum. Therefore,the correct option is $(D)$.