Friedel-Crafts acylation reaction can be used | vedclass

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Question

(C) Friedel-Crafts acylation is an electrophilic aromatic substitution reaction. It requires an electron-rich aromatic ring to react with the acylium

Vedclass · Accepted Answer

$I$ and $II$

Vedclass · Answer

(C) Friedel-Crafts acylation is an electrophilic aromatic substitution reaction. It requires an electron-rich aromatic ring to react with the acylium ion.$1$. Compound $(I)$ (Anisole derivative) has a strong electron-donating $-OCH_3$ group,which activates the ring towards electrophilic substitution.$2$. Compound $(II)$ (Toluene derivative) has an electron-donating $-CH_3$ group,which also activates the ring.$3$. Compound $(III)$ (Nitrobenzene derivative) has a strongly electron-withdrawing $-NO_2$ group,which deactivates the ring,making it unreactive towards Friedel-Crafts acylation.$4$. Compound $(IV)$ (Aniline derivative) has a $-N(CH_3)_2$ group. Although it is electron-donating,the lone pair on the nitrogen atom coordinates with the Lewis acid catalyst (e.g.,$AlCl_3$),forming a complex that strongly deactivates the ring,thus preventing the reaction.Therefore,only compounds $(I)$ and $(II)$ can be obtained via Friedel-Crafts acylation.

Friedel-Crafts acylation reaction can be used to obtain the compounds:

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