Sickle cell anaemia disorder arises due to

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(B) Sickle cell anaemia is an autosome-linked recessive trait that can be transmitted from parents to the offspring when both the partners are carrier

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Substitution in a single base of $DNA$

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(B) Sickle cell anaemia is an autosome-linked recessive trait that can be transmitted from parents to the offspring when both the partners are carriers for the gene.This disease is controlled by a single pair of allele,$Hb^A$ and $Hb^S$.It is caused by a point mutation in the $\beta$-globin chain of the haemoglobin molecule.Specifically,there is a substitution of Glutamic acid $(Glu)$ by Valine $(Val)$ at the sixth position of the $\beta$-globin chain.This substitution occurs due to a single base pair change in the $DNA$ sequence,where the codon $GAG$ is mutated to $GUG$.

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