Sickle cell anaemia is due to

Name: Exam Paper Generator | JEE NEET Paper Generator | Vedclass
Brand: Vedclass
Rating: 5 (35 reviews)

Question

(C) Sickle cell anaemia is an autosomal recessive genetic disorder caused by a point mutation in the $\beta$-globin gene of the haemoglobin molecule.T

Vedclass · Accepted Answer

$A$ genetically determined defect of haemoglobin synthesis

Vedclass · Answer

(C) Sickle cell anaemia is an autosomal recessive genetic disorder caused by a point mutation in the $\beta$-globin gene of the haemoglobin molecule.This mutation leads to the substitution of glutamic acid by valine at the $6^{th}$ position of the $\beta$-globin chain.As a result,the haemoglobin molecule undergoes polymerisation under low oxygen tension,causing the red blood cells to change their shape from biconcave discs to elongated sickle-like structures.

Column-$I$	Column-$II$
$a.$ Solid symbol	$(i)$ Carrier of sex-linked trait
$b.$ Horizontal line between symbols	$(ii)$ Offspring
$c.$ Horizontal line above the symbols	$(iii)$ Affected individual (Trait to be studied)
$d.$ Dot in centre	$(iv)$ Mating (Parents)

Similar Questions

Which of the following disorders is characterized by mental retardation?

If a son is affected by hemophilia,from whom is the probability of inheriting this disease?

Albinism is known to be due to an autosomal recessive mutation. The first child of a couple with normal skin pigmentation was an albino. What is the probability that their second child will also be an albino (in $\%$)?

In sickle-cell anaemia,which of the following amino acids is substituted?

Vedclass Test Series

Exam Paper Generator

Online Exam Module