The dipeptide,Gln-Gly,on treatment with CH_3C | vedclass

Name: Exam Paper Generator | JEE NEET Paper Generator | Vedclass
Brand: Vedclass
Rating: 5 (35 reviews)

Question

(D) The dipeptide $Gln-Gly$ consists of Glutamine $(Gln)$ at the $N$-terminus and Glycine $(Gly)$ at the $C$-terminus. The structure of $Gln-Gly$ is $

Vedclass · Accepted Answer

Vedclass · Answer

(D) The dipeptide $Gln-Gly$ consists of Glutamine $(Gln)$ at the $N$-terminus and Glycine $(Gly)$ at the $C$-terminus. The structure of $Gln-Gly$ is $H_2N-CH(CH_2CH_2CONH_2)-CONH-CH_2-COOH$.When treated with $CH_3COCl$ (acetyl chloride),the primary amino group $(-NH_2)$ at the $N$-terminus is acetylated to form an acetamide group $(-NHCOCH_3)$.The amide group $(-CONH_2)$ present in the side chain of Glutamine is significantly less nucleophilic due to resonance stabilization and is generally not acetylated under these conditions.Therefore,the product is $CH_3CONH-CH(CH_2CH_2CONH_2)-CONH-CH_2-COOH$,which corresponds to the structure shown in option $D$.

The dipeptide,$Gln-Gly$,on treatment with $CH_3COCl$ followed by aqueous work-up gives:

Similar Questions

The general structure of $\alpha$-amino acid can be represented as shown below. Which amino acid is not correctly matched with the $R$ group given?

Which of the following is $NOT$ a globular protein?

Which of the following will not give a purple color with ninhydrin?

Assertion : Haemoglobin is an oxygen carrier.
Reason : Oxygen binds as $O_2^-$ to $Fe$ of haemoglobin.

Assertion : Proteins are made up of $\alpha-$ amino acids.
Reason : During denaturation,secondary and tertiary structures of proteins are destroyed.

Vedclass Test Series

Exam Paper Generator

Online Exam Module