What triggers activation of protoxin to activ | vedclass

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(C) $Bacillus$ $thuringiensis$ $(Bt)$ produces insecticidal protein crystals during a particular phase of their growth. These crystals contain a toxic

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Alkaline $pH$ of gut

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(C) $Bacillus$ $thuringiensis$ $(Bt)$ produces insecticidal protein crystals during a particular phase of their growth. These crystals contain a toxic insecticidal protein. The protein exists as an inactive protoxin but becomes an active toxin when ingested by the insect. The activation of the toxin is triggered by the alkaline $pH$ of the insect's gut, which solubilizes the crystals. Once activated, the toxin binds to the surface of midgut epithelial cells and creates pores that cause cell swelling and lysis, eventually leading to the death of the insect.

What triggers activation of protoxin to active $Bt$ toxin of Bacillus thuringiensis in bollworm?

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