Which of the following reagent(s) is/are used | vedclass

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(A) The starting material is an ester containing a ketone group. Direct reduction with $LiAlH_4$ would reduce both the ketone and the ester groups to

Vedclass · Accepted Answer

glycol$/LiAlH_4/H_3O^{+}$

Vedclass · Answer

(A) The starting material is an ester containing a ketone group. Direct reduction with $LiAlH_4$ would reduce both the ketone and the ester groups to alcohols. To selectively reduce the ester to an alcohol while keeping the ketone intact,we must first protect the ketone.$1$. The ketone is protected by forming a cyclic acetal using ethylene glycol (glycol) in the presence of an acid catalyst.$2$. The ester group is then reduced to a primary alcohol using $LiAlH_4$.$3$. Finally,the cyclic acetal is deprotected (hydrolyzed) back to the ketone using $H_3O^{+}$.

Which of the following reagent$(s)$ is/are used for the given conversion?

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