Which of the following statements are correct with reference to the packaging of the $DNA$ helix?

  • A
    $A$. Histones are organized to form a unit of eight molecules called a histone octamer.
  • B
    $B$. Histones are negatively charged basic proteins.
  • C
    $C$. Histones are rich in the basic amino acid residues - lysine and arginine.
  • D
    $D$. The positively charged $DNA$ is wrapped around the histone octamer to form a nucleosome. $E$. The packaging of chromatin at higher levels requires an additional set of proteins called non-histone chromosomal proteins.

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