Which of the following statements is correct?

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(A) $1$. Haemophilia is an $X$-linked recessive disorder. $A$ female carrier $(X^HX^h)$ has a $50\%$ chance of passing the defective $X^h$ chromosome

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Female carrier for haemophilia may transmit the disease to sons.

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(A) $1$. Haemophilia is an $X$-linked recessive disorder. $A$ female carrier $(X^HX^h)$ has a $50\%$ chance of passing the defective $X^h$ chromosome to her sons,who will then express the disease.$2$. Thalassemia is a quantitative problem because it involves the reduced synthesis of one of the globin chains of the haemoglobin molecule.$3$. $A$ change in the whole set of chromosomes is called polyploidy,whereas aneuploidy refers to the gain or loss of one or more individual chromosomes.$4$. Sickle cell anaemia is a qualitative problem because it results from a point mutation in the gene coding for the $\beta$-globin chain,leading to the substitution of glutamic acid with valine,which alters the structure and function of the haemoglobin molecule.

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