Which one of the following disorders is cause | vedclass

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(C) Sickle-cell anaemia is an autosomal linked recessive trait that can be transmitted from parents to the offspring when both the partners are carrie

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$(3)$ Sickle-cell anaemia

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(C) Sickle-cell anaemia is an autosomal linked recessive trait that can be transmitted from parents to the offspring when both the partners are carriers for the gene.This genetic disorder is caused by a point mutation in the gene coding for the beta-globin chain of haemoglobin.Specifically, at the sixth position of the beta-globin chain, the amino acid Glutamic acid (Glu) is replaced by Valine (Val).This substitution leads to the formation of abnormal haemoglobin molecules, which cause red blood cells to change their shape into a sickle-like structure under low oxygen tension.

Which one of the following disorders is caused by the substitution of Glutamic acid (Glu) by Valine (Val) at the sixth position of the beta globin chain of the haemoglobin molecule?

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