In sickle-cell anemia,what is the sequence of | vedclass

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Question

(B) Sickle-cell anemia is caused by a point mutation in the $\beta$-globin gene of hemoglobin.In the normal gene,the template strand has the sequence

Vedclass · Accepted Answer

$GTG$

Vedclass · Answer

(B) Sickle-cell anemia is caused by a point mutation in the $\beta$-globin gene of hemoglobin.In the normal gene,the template strand has the sequence $CTC$,which codes for $GAG$ in mRNA,resulting in the amino acid Glutamic acid.In the mutated gene,the $CTC$ sequence on the template strand changes to $CAC$.Consequently,the non-template (coding) strand,which carries the same sequence as the mRNA (except $T$ instead of $U$),changes from $GAG$ to $GTG$.Therefore,the defective sequence on the non-template strand is $GTG$.

In sickle-cell anemia,what is the sequence of the defective nitrogen base on the $DNA$ strand that does not act as a template?

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