Select the option that represents the correct sequence of steps in $r-DNA$ technology.
$(1)$ Insertion of $r-DNA$ into the host
$(2)$ Isolation of $DNA$
$(3)$ Ligation of $DNA$ fragment into the vector
$(4)$ Culturing the host cells in a medium at a large scale and extraction of the desired product
$(5)$ Isolation of the desired $DNA$ fragment
$(6)$ Fragmentation of $DNA$ by restriction endonucleases

• A
  $2 \rightarrow 6 \rightarrow 3 \rightarrow 1 \rightarrow 5 \rightarrow 4$
• B
  $1 \rightarrow 3 \rightarrow 4 \rightarrow 6 \rightarrow 5 \rightarrow 2$
• C
  $2 \rightarrow 6 \rightarrow 5 \rightarrow 3 \rightarrow 1 \rightarrow 4$
• D
  $6 \rightarrow 1 \rightarrow 3 \rightarrow 4 \rightarrow 2 \rightarrow 5$