Which vaccine was the first to be tested using transgenic mice?

Transgenic organisms are produced by:

Genetic engineering has been successfully used for producing

In transgenesis,the expression of the transgene in the target tissue is known as:

Genetic engineering is useful for the production of?

Read the following four statements $(A-D)$ and identify the mistakes in two of them.
$(A)$ The first transgenic cow,Rosie,produced milk which was human alpha-lactalbumin enriched.
$(B)$ Restriction enzymes are used in the isolation of $DNA$ from other macromolecules.
$(C)$ Downstream processing is one of the steps of $rDNA$ technology.
$(D)$ Disarmed pathogen vectors are also used in the transfer of $rDNA$ into the host.
Which of the two statements have mistakes?