Adenosine deaminase (ADA) deficiency is most | vedclass

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(C) The correct answer is $C$. Adenosine deaminase $(ADA)$ deficiency is a severe combined immunodeficiency $(SCID)$ disorder. It is most commonly cau

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Deletion

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(C) The correct answer is $C$. Adenosine deaminase $(ADA)$ deficiency is a severe combined immunodeficiency $(SCID)$ disorder. It is most commonly caused by a deletion in the gene that codes for the enzyme adenosine deaminase. This enzyme is crucial for the proper functioning of the immune system,specifically for the maturation of $T$-lymphocytes. The absence of this enzyme leads to the accumulation of toxic metabolites,which destroy the immune cells.

List-$I$	List-$II$
$A$. Genetically engineered Human Insulin	$I$. Gene therapy
$B$. $\text{GM}$ Cotton	$II$. $\text{E. coli}$
$C$. $\text{ADA}$ Deficiency	$III$. Antigen-antibody interaction
$D$. $\text{ELISA}$	$IV$. $\text{Bacillus thuringiensis}$

Adenosine deaminase $(ADA)$ deficiency is most commonly caused by which genetic abnormality?

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