Decarboxylation is observed to be fastest in

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(A) Decarboxylation of $\beta$-keto acids is very fast because it proceeds through a stable six-membered cyclic transition state involving hydrogen bo

Vedclass · Accepted Answer

$A. 	ext{3-oxobutanoic acid}$

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(A) Decarboxylation of $\beta$-keto acids is very fast because it proceeds through a stable six-membered cyclic transition state involving hydrogen bonding between the carboxylic acid hydrogen and the carbonyl oxygen of the $\beta$-keto group.Among the given options,$	ext{3-oxobutanoic acid}$ $(CH_3COCH_2COOH)$ is a $\beta$-keto acid.In this molecule,the carbonyl group is at the $\beta$-position relative to the carboxyl group,which facilitates the formation of the cyclic transition state,leading to rapid loss of $CO_2$ upon heating.Other options do not possess the $\beta$-keto group arrangement required for this specific mechanism.

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