Haemophilia is more commonly seen in human ma | vedclass

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(C) Haemophilia is a sex-linked recessive disorder.It is caused by a mutation in the genes located on the $X$ chromosome.In human males,there is only

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This disease is due to an $X$-linked recessive mutation

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(C) Haemophilia is a sex-linked recessive disorder.It is caused by a mutation in the genes located on the $X$ chromosome.In human males,there is only one $X$ chromosome $(XY)$. If the $X$ chromosome carries the recessive mutant gene,the male will express the disease because there is no corresponding allele on the $Y$ chromosome to mask its effect.In contrast,human females have two $X$ chromosomes $(XX)$. For a female to express the disease,she must be homozygous for the recessive allele $(X^hX^h)$. If she has only one recessive allele $(X^hX)$,she remains a carrier and does not show the disease phenotype.Therefore,the disease is much more common in males than in females.

Haemophilia is more commonly seen in human males than in human females because

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