Mutations induced by 5-bromouracil are known | vedclass

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(B) $5$-bromouracil ($5$-$BU$) is a base analog of thymine. It can exist in two tautomeric forms: the keto form and the enol form. In its keto form,$5

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Transition mutations

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(B) $5$-bromouracil ($5$-$BU$) is a base analog of thymine. It can exist in two tautomeric forms: the keto form and the enol form. In its keto form,$5$-$BU$ pairs with adenine,similar to thymine. However,in its enol form,it can pair with guanine. During $DNA$ replication,if $5$-$BU$ is incorporated into the $DNA$ strand in place of thymine and undergoes a tautomeric shift to the enol form,it will pair with guanine instead of adenine. In the subsequent round of replication,this guanine will pair with cytosine,resulting in a $T:A$ to $C:G$ base pair substitution. Since this involves the substitution of a purine for a purine or a pyrimidine for a pyrimidine,it is classified as a transition mutation.

Mutations induced by $5$-bromouracil are known as:

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