Sickle-cell anaemia is caused by the followin | vedclass

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(A) The correct answer is $GAG-GUG$ (at the mRNA level) or $CTC-CAC$ (at the $DNA$ template strand level).In sickle-cell anaemia,a point mutation occu

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$CTC$-$CAC$

Vedclass · Answer

(A) The correct answer is $GAG-GUG$ (at the mRNA level) or $CTC-CAC$ (at the $DNA$ template strand level).In sickle-cell anaemia,a point mutation occurs in the $\beta$-globin gene.Specifically,the codon $GAG$ (coding for glutamic acid) is mutated to $GUG$ (coding for valine) at the sixth position of the $\beta$-globin chain.At the $DNA$ level,the template strand codon $CTC$ is mutated to $CAC$,which results in the transcription of $GUG$ instead of $GAG$.This substitution of valine for glutamic acid causes the haemoglobin molecules to polymerize under low oxygen tension,leading to the characteristic sickle shape of the red blood cells.

Sickle-cell anaemia is caused by the following mutant gene mutation ($DNA$ level):

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