The ease of hydrolysis in the compounds CH_3C | vedclass

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(A) The reactivity of carboxylic acid derivatives towards nucleophilic acyl substitution (such as hydrolysis) depends on the leaving group ability of

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$I > II > III > IV$

Vedclass · Answer

(A) The reactivity of carboxylic acid derivatives towards nucleophilic acyl substitution (such as hydrolysis) depends on the leaving group ability of the substituent attached to the acyl group.The weaker the base, the better the leaving group.The order of basicity of the leaving groups is $Cl^{-} Therefore, the order of leaving group ability is $Cl^{-} > CH_3COO^{-} > C_2H_5O^{-} > NH_2^-$.Thus, the order of ease of hydrolysis is: $CH_3COCl$ $(I) > (CH_3CO)_2O$ $(II) > CH_3COOC_2H_5$ $(III) > CH_3CONH_2$ $(IV)$.

The ease of hydrolysis in the compounds $CH_3COCl$ $(I)$, $(CH_3CO)_2O$ $(II)$, $CH_3COOC_2H_5$ $(III)$ and $CH_3CONH_2$ $(IV)$ is of the order:

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