The distortion of hemoglobin under low oxygen | vedclass

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(C) Sickle cell anemia is an autosome-linked recessive trait that can be transmitted from parents to the offspring when both the partners are carrier

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Sickle cell anemia

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(C) Sickle cell anemia is an autosome-linked recessive trait that can be transmitted from parents to the offspring when both the partners are carrier for the gene.In this disease,the hemoglobin molecule undergoes polymerization under low oxygen tension,causing the change in the shape of the red blood cell from a biconcave disc to an elongated sickle-like structure.This distortion occurs due to a single base substitution at the sixth codon of the $\beta -$globin gene from $GAG$ to $GUG$,resulting in the substitution of glutamic acid by valine.

The distortion of hemoglobin under low oxygen tension is a characteristic of which of the following?

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