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(B) Sickle-cell anemia is an autosome-linked recessive trait that can be transmitted from parents to the offspring when both the partners are carriers

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Change in amino acids in the $\beta$-chain of hemoglobin

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(B) Sickle-cell anemia is an autosome-linked recessive trait that can be transmitted from parents to the offspring when both the partners are carriers for the gene. This disease is controlled by a single pair of allele,$Hb^A$ and $Hb^S$. The defect is caused by the substitution of Glutamic acid $(Glu)$ by Valine $(Val)$ at the sixth position of the $\beta$-globin chain of the hemoglobin molecule. This substitution occurs due to the single base pair substitution at the sixth codon of the $\beta$-globin gene from $GAG$ to $GUG$.

Sickle-cell anemia is caused by a change in which of the following?

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